Fasting :: Intermittent Fasting :: Periodic Fasting

Fasting in all its various forms (overnight fasting, 14-16 hour intermittent fasting, 24-hour, 5 day, etc.) has long been promoted for various health benefits. In Germany and Russia, there are even clinics that offer “therapeutic fasting” to help detox the body and mind. These types of clinics and fasting as a therapeutic modality have not been very popular in the U.S., but thanks to the work of Valter Longo, Ph.D. and other experts, we have learned about specific mechanisms that bring about health benefits from fasting. Also, it is important to note that each type of fasting has a unique impact and turns on a completely different process in the body.

In a new book, The Longevity Diet: Discover the New Science Behind Stem Cell Activation and Regeneration to Slow Aging, Fight Disease, and Optimize Weight (released January 2018), Dr. Longo teaches us that it is not just about what you eat, but when you eat that impacts your health and longevity. More importantly, we learn that fasting may help address the chronic illnesses we face today.

Many of the world’s leading scientists on fasting, have been and continue to conduct research on fasting as a way to deal with obesity, diabetes, cancer, cardiovascular problems, skin problems, high blood pressure, chronic headaches, joint pain, and many other health concerns.

At the Longevity Institute at the University of Southern California’s Leonard Davis School of Gerontology in sponsorship by the National Institute for Aging (NIA) and the National Institutes of Health (NIH), Dr. Longo developed the Fasting Mimicking Diet (FMD) called ProLon. See below for more information.


A Better You In Just 5 Days

ProLon® is a five-day meal program that is scientifically proven and clinically tested to induce the health benefits of water-only fasting—healthy aging, cell regeneration, and fat-driven weight loss—but without the same discomforts and risks.

Benefits of the Fasting Mimicking Diet

Performance Optimization:
Optimize both muscle and mental performance, as well as greater focus, clarity and energy.

Fat Focused Weight Loss:
Fastest way to lose fat (especially belly fat) while protecting lean body mass.

Cellular Functional Optimization:
Trigger stem cell-based regeneration and autophagy, (the clean up of aging & damaged cells) and promote stem cell-based renewal.

Metabolic Health:
Maintain healthy levels of blood glucose, cholesterol and blood pressure, as well as markers of inflammation for overall wellness.

Fasting Mimicking Diet Patent

Patent Number: US9237761 B2
Publication Date: Jan 19, 2016

Inventors: Valter D. Longo, Sebastian Brandhorst, Morgan Elyse Levine

A method of improving longevity and/or alleviating a symptom of aging or preventing age related diseases is provided.

Clinical Results

Extensive Clinical Study Results available in which the Fasting Mimicking Diets (FMD) have been shown to help…

  • Decrease Weight and Body Fat
  • Stem Cell Regeneration
  • Maintain Glucose at Healthy Levels
  • Maintain CRP at Healthy Levels
  • Maintain Triglycerides at Healthy Levels
  • Maintain Blood Pressure at Healthy Levels
  • Maintain Healthy Levels of Bone Density
  • Impact in IGF-1 (Aging Marker)
  • Maintain Insulin Resistance at Healthy Levels
  • Maintain Cholesterol at Healthy Levels
  • Decrease Visceral Fat

Individual Results May Vary

The ingredients in ProLon are considered generally recognized as safe (GRAS). ProLon is not intended to diagnose, treat, cure or prevent any diseases and has not been evaluated as such by the FDA.



The Longevity Diet: Discover the New Science Behind Stem Cell Activation and Regeneration to Slow Aging, Fight Disease and Optimize Weight by Valter Longo, Ph.D., Director of the Longevity Institute, USC

About the Book

Can what you eat determine how long, and how well, you live? The clinically proven answer is yes, and The Longevity Diet is easier to follow than you’d think. The culmination of 25 years of research on aging, nutrition, and disease across the globe, this unique combination of an everyday diet and fasting-mimicking diet (FMD) to be done only 3-4 times per year lays out a simple solution to living to a healthy old age through nutrition.

FMD does away with the misery and starvation most of us experience while fasting and helps you reap all the beneficial health effects of a restrictive diet while avoiding the negative stressors, like low energy and sleeplessness.

Valter Longo, Director of the Longevity Institute at USC and the Program on Longevity and Cancer at IFOM in Milan, developed the FMD after making a series of remarkable discoveries in mice and humans indicating that specific diets can activate stem cells and promote regeneration and rejuvenation in multiple organs to reduce the risk for diabetes, cancer, Alzheimer’s and heart disease. Longo’s simple pescatarian daily eating plan and the periodic, fasting-mimicking techniques can both yield impressive results. Low in proteins and sugars and rich in healthy fats and plant-based foods, The Longevity Diet is clinically proven to help you:

  • Lose weight and reduce abdominal fat
  • Make simple changes which can extend the healthy lifespan
  • Prevent age-related muscle and bone loss
  • Build your resistance to diabetes, cardiovascular disease, Alzheimer’s and cancer

Longo’s healthy, life span-extending plan is based on an easy-to-adopt pescatarian plan along with the fasting-mimicking diet 4 times a year, and just 5 days at a time. Including 30 easy recipes for an everyday diet based on Longo’s five pillars of longevity, The Longevity Diet is the key to living a longer, healthier, and fulfilled life.

About the Author

Valter Longo, Ph.D. is the Director of the Longevity Institute at USC and the Program on Longevity and Cancer at IFOM in Milan, Italy. He is also the Founder of the Create Cures Foundation,

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This website is for information purposes only. With the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional. Furthermore, the information in our articles are NOT intended to replace a one-on-one relationship with a qualified health care professional and are not intended as medical  advice.